Ukwenziwa kwe-Astaxanthin ku-Chlamydomonas Reinhardtii

I-PROTOGA isanda kumemezela ukuthi iphumelele ekukhiqizeni i-astaxanthin yemvelo ku-Chlamydomonas Reinhardtii nge-Microalgae Genetic Modification Platform, futhi manje ithuthukisa ucwaningo oluhlobene lwempahla yobuhlakani kanye nokucubungula okulandelayo. Kubikwa ukuthi lesi yisizukulwane sesibili samaseli obunjiniyela abekwe emgudwini we-astaxanthin futhi sizoqhubeka nokukhula. Isizukulwane sokuqala samaseli obunjiniyela singene esigabeni sokuhlola sokuhlola. Ukwenziwa kwe-astaxanthin ku-Chlamydomonas Reinhardtii ekukhiqizweni kwezimboni kungaba ngcono ngezindleko, ukukhiqiza kanye nekhwalithi kunokwe-Haematococcus Pluvialis.

I-Astaxanthin iyi-xanthophyll yemvelo neyokwenziwa kanye ne-carotenoid engeyona i-provitamin A, enemisebenzi engaba khona yokulwa ne-antioxidant, ukulwa nokuvuvukala kanye ne-antineoplastic. Umsebenzi wayo we-antioxidant uphindwe izikhathi ezingu-6000 kunovithamini C kanye nezikhathi ezingu-550 kunovithamini E. I-Astaxanthin isebenza kahle kakhulu ekulawuleni amasosha omzimba, ekugcinweni kwesimiso senhliziyo nemithambo yegazi, empilweni yamehlo nobuchopho, empilweni yesikhumba, ekulweni nokuguga kanye nezinye izinhlelo zokusebenza. I-Astaxanthin ivame ukusetshenziswa emikhiqizweni yokunakekelwa kwempilo, emikhiqizweni yokudla okunempilo enomphumela wokunakekelwa kwempilo futhi ingezwe ezimonyweni zobuhle ezinomphumela we-antioxidant.

Imakethe ye-astaxanthin yomhlaba wonke kulindeleke ukuthi ifinyelele ku-$2.55 billion ngo-2025 ngokusho kwe-Grand View Research. Njengamanje, umsebenzi we-astaxanthin otholakala ngokwenziwa kwamakhemikhali kanye ne-Phaffia rhodozyma uphansi kakhulu kunowe-levo-astaxanthin yemvelo etholakala ku-microalgae ngenxa yomsebenzi wayo wokukhanya wesakhiwo. Yonke i-levo-astaxanthin yemvelo emakethe ivela ku-Haematococcus Pluvialis. Kodwa-ke, ngenxa yokukhula kwayo okuhamba kancane, umjikelezo omude wokukhula kanye nokuthinteka kalula yizici zemvelo, amandla okukhiqiza e-Haematococcus Pluvialis anqunyelwe.

Njengomthombo omusha wemikhiqizo yemvelo kanye neseli le-chassis yebhayoloji yokwenziwa, i-microalgae inenethiwekhi eyinkimbinkimbi kakhulu ye-metabolic kanye nezinzuzo ze-biosynthesis. I-Chlamydomonas Reinhardtii iyi-chassis yephethini, eyaziwa ngokuthi "imvubelo eluhlaza". I-PROTOGA inolwazi lobuchwepheshe bokuhlela izakhi zofuzo ze-microalgae obuthuthukisiwe kanye nobuchwepheshe bokuvutshelwa kwe-microalgae obuphansi. Ngesikhathi esifanayo, i-PROTOGA ithuthukisa ubuchwepheshe be-photoautotrophic. Uma ubuchwepheshe bokuzalanisa sebuvuthiwe futhi bungasetshenziswa ekukhiqizweni kwesikali, buzophakamisa ukusebenza kahle kokwenziwa okuguqula i-CO2 ibe yimikhiqizo esekelwe ku-bio.