Kev tsim cov astaxanthin hauv Chlamydomonas Reinhardtii

PROTOGA nyuam qhuav tshaj tawm tias nws tau ua tiav synthesized ntuj astaxanthin hauv Chlamydomonas Reinhardtii los ntawm Microalgae Genetic Modification Platform, thiab tam sim no tab tom tsim cov cuab yeej cuab tam thiab kev tshawb fawb txog kev ua haujlwm downstream. Nws tau tshaj tawm tias qhov no yog tiam thib ob ntawm cov hlwb engineering uas tau teeb tsa hauv astaxanthin pipeline thiab yuav txuas ntxiv mus. Thawj tiam ntawm cov hlwb engineering tau nkag mus rau theem sim tsav. Kev synthesizing ntawm astaxanthin hauv Chlamydomonas Reinhardtii rau kev tsim khoom lag luam yuav zoo dua hauv tus nqi, kev tsim khoom thiab zoo dua li ntawm Haematococcus Pluvialis.

Astaxanthin yog ib hom xanthophyll thiab nonprovitamin A carotenoid uas yog los ntawm ntuj thiab tsim los, nws muaj peev xwm ua antioxidant, anti-inflammatory thiab antineoplastic activity. Nws cov antioxidant activity yog 6000 npaug ntawm vitamin C thiab 550 npaug ntawm vitamin E. Astaxanthin muaj kev ua tau zoo heev hauv kev tswj hwm kev tiv thaiv kab mob, kev saib xyuas lub plawv, kev noj qab haus huv ntawm qhov muag thiab lub hlwb, kev ua kom tawv nqaij muaj zog, tiv thaiv kev laus thiab lwm yam kev siv. Astaxanthin feem ntau siv rau hauv cov khoom kho mob, cov khoom noj khoom haus uas muaj txiaj ntsig zoo rau kev kho mob thiab ntxiv rau hauv cov tshuaj pleev ib ce uas muaj txiaj ntsig zoo rau kev tiv thaiv kab mob.

Lub lag luam thoob ntiaj teb astaxanthin yuav tsum ncav cuag $ 2.55 billion los ntawm 2025 raws li Grand View Research. Tam sim no, cov haujlwm ntawm astaxanthin tau los ntawm kev tsim tshuaj lom neeg thiab Phaffia rhodozyma qis dua li ntawm cov levo-astaxanthin ntuj uas tau los ntawm microalgae vim nws cov haujlwm kho qhov muag. Txhua yam levo-astaxanthin ntuj hauv kev ua lag luam los ntawm Haematococcus Pluvialis. Txawm li cas los xij, vim nws txoj kev loj hlob qeeb, lub voj voog kab lis kev cai ntev thiab yooj yim raug cuam tshuam los ntawm cov yam ntxwv ib puag ncig, lub peev xwm tsim khoom ntawm Haematococcus Pluvialis yog txwv.

Ua ib qho chaw tshiab ntawm cov khoom ntuj thiab lub chassis cell ntawm cov khoom siv hluavtaws, microalgae muaj cov txiaj ntsig ntawm kev sib txuas lus metabolic thiab biosynthesis ntau dua. Chlamydomonas Reinhardtii yog tus qauv chassis, hu ua "yeast ntsuab". PROTOGA tau ua tus tswv ntawm cov thev naus laus zis kho cov noob caj noob ces microalgae thiab cov thev naus laus zis fermentation microalgae. Tib lub sijhawm, PROTOGA tab tom tsim cov thev naus laus zis photoautotrophic. Thaum cov thev naus laus zis yug me nyuam tiav lawm thiab tuaj yeem siv rau ntawm qhov ntau thiab tsawg, nws yuav ua rau cov txiaj ntsig synthesis hloov CO2 mus rau cov khoom siv bio-based.