Ukufunyanwa kwee-Microalgae Extracellular Vesicles

Ii-vesicles ze-extracellular zii-vesicles ze-nano-size ze-endogenous ezikhutshwa ziiseli, ukusuka kwi-30-200 nm ububanzi ezigqunywe yi-lipid bilayer membrane, ethwala ii-nucleic acids, iiproteni, ii-lipids kunye ne-metabolites, njl. Ii-vesicles ze-extracellular zezona zixhobo ziphambili zonxibelelwano phakathi kweeseli, ezibandakanyeka ekutshintshiselaneni kwezinto phakathi kweeseli. Ii-vesicles ze-extracellular zinokukhutshwa ziiseli ezahlukeneyo phantsi kweemeko eziqhelekileyo neziyi-pathological, ezivela ikakhulu kwi-polyvesicles ezenziwe zii-intracellular lysosomal particles kwaye zikhutshwa kwi-extracellular matrix emva kokudibana kwe-extracellular membrane kunye ne-cell membrane ye-polyvesicles. Ngenxa ye-immunogenicity yayo ephantsi, iziphumo ebezingalindelekanga ezingezizo ezinobungozi, ukujolisa okunamandla, amandla okuwela umqobo wegazi-ubuchopho kunye nezinye iimpawu, ithathwa njengesixhobo esinokuba ngumthwali weziyobisi. Ngo-2013, iMbasa yeNobel kwiPhysiology and Medicine yanikezelwa kwizazinzulu ezintathu ezinxulumene nophando lwee-external vesicles. Ukususela ngoko, imibutho yezemfundo neyezoshishino iye yabangela ukwanda kophando nophuhliso lwe-extracellular vesicles, ukusetyenziswa kunye nokuthengiswa.

Ii-vesicles ezingaphandle kweseli ezivela kwiiseli zezityalo zityebile kwizinto ezisebenzayo ezizodwa, zincinci ngobukhulu kwaye ziyakwazi ukungena kwizicubu. Uninzi lwazo lunokuthathwa luze lufunxwe ngqo emathunjini. Umzekelo, ii-vesicles ze-ginseng zinceda ekuhlukaniseni iiseli ze-stem zibe ziiseli zemithambo-luvo, kwaye ii-vesicles ze-ginger zinokulawula izityalo zamathumbu kwaye zinciphise i-colitis. Ii-Microalgae zezona zityalo zindala ezineseli enye eMhlabeni. Kukho phantse iintlobo ezingama-300,000 ze-microalgae ezisasazeke kakhulu kwiilwandle, emachibini, emilanjeni, entlango, kwiintlambo, kwiiqhwa nakwezinye iindawo, ezineempawu ezizodwa zengingqi. Ngexesha lokuvela koMhlaba oziibhiliyoni ezi-3, ii-microalgae bezisoloko zikwazi ukukhula njengeeseli ezizimeleyo eMhlabeni, nto leyo engenakwahlulwa kukukhula kwazo okumangalisayo kunye nokukwazi ukuzilungisa.

Ii-microalgal extracellular vesicles zizinto ezintsha ezisebenzayo ze-biomedical ezinokhuseleko oluphezulu kunye nozinzo. Ii-Microalgae zineengenelo ezininzi ekuvelisweni kwee-extracellular vesicles, ezifana nenkqubo elula yokukhulisa, elawulekayo, engabizi, ekhula ngokukhawuleza, imveliso ephezulu yee-vesicles kunye noyilo olulula ukuyilwa. Kwizifundo zangaphambili, ii-microalgal extracellular vesicles zifunyenwe ukuba zifakwa ngaphakathi ngokulula ziiseli. Kwiimodeli zezilwanyana, zifunyenwe ukuba zifunxwa ngqo ngamathumbu kwaye zityetyiswe kwiithishu ezithile. Emva kokungena kwi-cytoplasm, inokuhlala iintsuku ezininzi, nto leyo enceda ukukhululwa kweziyobisi ixesha elide.

Ukongeza, kulindeleke ukuba ii-microalgal extracellular vesicles zilayishe amayeza ahlukeneyo, aphucula uzinzo lwee-molecules, ukukhululwa kancinci, ukulungelelaniswa nomlomo, njl.njl., ukusombulula imiqobo ekhoyo yokulawulwa kwamayeza. Ke ngoko, uphuhliso lwee-microalgae extracellular vesicles lunokwenzeka kakhulu ekuguqulweni kweklinikhi nasekuphuhlisweni kwemizi-mveliso.