Kuwanikwa kweMicroalgae Extracellular Vesicles

Ma vesicles ekunze kwemasero i vesicles dzemhando yepamusoro dzinoburitswa nemasero, dzine dhayamita kubva pa30–200 nm dzakaputirwa ne lipid bilayer membrane, inotakura nucleic acids, mapuroteni, lipids uye metabolites, nezvimwewo. Ma vesicles ekunze kwemasero ndiwo maturusi makuru ekutaurirana pakati pemasero, ayo anobatanidzwa mukutsinhana kwezvinhu pakati pemasero. Ma vesicles ekunze kwemasero anogona kuburitswa nemasero akasiyana-siyana pasi pemamiriro ezvinhu akajairwa uye ezvirwere, ayo anonyanya kubva kuma polyvesicles anoumbwa ne intracellular lysosomal particles uye anoburitswa mu extracellular matrix mushure mekusanganiswa kwe extracellular membrane ne cell membrane ye polyvesicles. Nekuda kwekusasimba kwe immunogenicity kwayo, migumisiro isina chepfu, kunanga kwakasimba, kugona kuyambuka chipingamupinyi cheropa-uropi nezvimwe zvinhu, yave ichionekwa semushonga unogona kutakurwa. Muna 2013, Mubairo weNobel muPhysiology neMishonga wakapihwa kumasayendisiti matatu ane chekuita nekudzidza ma vesicles ekunze. Kubva ipapo, masangano edzidzo nemaindasitiri akatanga kuwedzera kwekutsvaga nekugadzira ma vesicles ari kunze kwemuviri, kushandiswa kwawo uye kutengeserana.

Ma vesicles ari kunze kwemasero anobva mumasero emiti ane zvinhu zvakasiyana-siyana zvinoshanda, madiki muhukuru uye anokwanisa kupinda munyama. Mazhinji acho anogona kutorwa onyudzwa zvakananga muura. Semuenzaniso, ma vesicles e ginseng anobatsira pakusiyanisa masero ekutanga kuita masero etsinga, uye ma vesicles e ginger anogona kudzora maruva emudumbu uye kuderedza colitis. Microalgae ndiyo miti yekare ine sero rimwe chete pasi rose. Kune mhando dzinosvika 300,000 dze microalgae dzakapararira zvakanyanya mumakungwa, munyanza, munzizi, mumagwenga, munzvimbo dzakatetepa, munzvimbo dzechando nedzimwe nzvimbo, dzine hunhu hwakasiyana hwenzvimbo. Munguva yekushanduka kweNyika ine mabhiriyoni matatu, microalgae yagara ichikwanisa kubudirira semasero rimwe chete pasi pano, izvo zvisingaparadzaniswi nekukura kwavo kunoshamisa uye kugona kwavo kuzvigadzirisa.

Ma microalgal extracellular vesicles zvinhu zvitsva zvinoshanda zvekurapa zvine kuchengetedzeka kwakanyanya uye kugadzikana. Ma microalgae ane zvakanakira zvakawanda mukugadzirwa kwema extracellular vesicles, zvakaita sekuita kuri nyore kurima, kudzorwa, kudhura, kukura nekukurumidza, kubuda kwakanyanya kwema vesicles uye nyore kugadzirwa. Muzvidzidzo zvekare, ma microalgal extracellular vesicles akawanikwa achiiswa mukati memasero zviri nyore. Mumhando dzemhuka, akawanikwa achinyudzwa zvakananga nemudumbu uye achiwedzerwa mumatishu chaiwo. Mushure mekupinda mu cytoplasm, anogona kugara kwemazuva akati wandei, izvo zvinoita kuti mushonga urambe uchiburitswa kwenguva refu.

Pamusoro pezvo, ma vesicle ekunze kwemasero emualgae anotarisirwa kurodha mishonga yakasiyana-siyana, iyo inovandudza kugadzikana kwemamorekuru, kuburitswa zvishoma nezvishoma, kugona kuchinjika nemuromo, nezvimwewo, kugadzirisa zvipingamupinyi zviripo zvekushandisa mishonga. Nokudaro, kugadzirwa kwema vesicle ekunze kwemasero emualgae kune mukana mukuru mukushandura kwekiriniki uye kusimudzira maindasitiri.