Kuwanikwa kweMicroalgae Extracellular Vesicles

Extracellular vesicles ari endogenous nano-size vesicles akadzivirirwa nemasero, kubva pa30-200 nm mudhayamita akafukidzwa mu lipid bilayer membrane, anotakura nucleic acids, mapuroteni, lipids uye metabolites, nezvimwewo. Extracellular vesicles ndiwo maturusi makuru ekutaurirana, izvo zvinobatanidzwa mukutsinhana kwezvinhu pakati pemasero.Extracellular vesicles inogona kuvanzwa nemhando dzakasiyana-siyana pasi pezvakajairwa uye pathological mamiriro, ayo anonyanya kubva kuma polyvesicles akaumbwa ne intracellular lysosomal particles uye anoburitswa mu extracellular matrix mushure mekusanganiswa kwe extracellular membrane uye cell membrane ye polyvesicles.Nekuda kweiyo yakaderera immunogenicity, isiri-chepfu mhedzisiro, yakasimba kunanga, kugona kuyambuka iyo yeropa-brain barriers uye humwe hunhu, yave ichionekwa seanogona kutakura zvinodhaka.Muna 2013, Mubairo weNobel muPhysiology uye Mushonga wakapihwa kune vatatu vesainzi vane chekuita nekudzidza kwemavhesi ekunze.Kubva ipapo, denderedzwa redzidzo nemaindasitiri rakatanga kuwedzera kwekuwedzera kwekutsvaga nekusimudzira, kushandisa uye kushambadzira.

Extracellular vesicles kubva kumaseru ezvirimwa akapfuma mune akasiyana anoshanda zvikamu, madiki muhukuru uye anokwanisa mukupinza kwenyama.Zvizhinji zvacho zvinogona kutorwa uye kunyudzwa zvakananga muura.Semuenzaniso, ma ginseng vesicles anobatsira pakusiyaniswa kwemasero etsinga mumasero etsinga, uye ginger vesicles inogona kudzora maruva emukati uye kuderedza colitis.Microalgae ndiyo yekare-sero-sero zvirimwa paNyika.Kune angangoita mazana matatu ezviuru emhando dzemicroalgae akaparadzirwa zvakanyanya mumakungwa, madziva, nzizi, magwenga, mapani, glaciers nedzimwe nzvimbo, ane akasiyana edunhu maitiro.Munguva yekushanduka kwe 3 bhiriyoni Earth, microalgae yagara ichikwanisa kubudirira sesero rimwe chete paPasi, iro risingaparadzaniswe nekukura kwavo kunoshamisa uye kugona kuzvigadzirisa.

Microalgal extracellular vesicles zvinhu zvitsva zvebiomedical zvinoshanda zvine kuchengetedzwa kwepamusoro uye kugadzikana.Microalgae ine akawanda mabhenefiti mukugadzirwa kweextracellular vesicles, senge yakapusa tsika muitiro, inodzoreka, yakachipa, kukurumidza kukura, yakakwira kubuda kwemavhesi uye nyore kugadzirwa.Muzvidzidzo zvakapfuura, microalgal extracellular vesicles yakawanikwa iri nyore kuiswa mukati nemasero.Mune mhando dzemhuka, dzakawanikwa dzakanyudzwa zvakananga kuburikidza nemudumbu uye dzakapfumiswa mune chaiyo tishu.Mushure mekupinda mu cytoplasm, inogona kugara kwemazuva akati wandei, izvo zvinokonzeresa kuburitswa kwenguva refu kwezvinodhaka.

Pamusoro pezvo, microalgal extracellular vesicles inotarisirwa kutakura mishonga yakasiyana-siyana, iyo inovandudza kugadzikana kwemamorekuru, kunonoka kusunungurwa, kugadzirisa kwemuromo, nezvimwewo, kugadzirisa zvipingamupinyi zviripo zvekutonga zvinodhaka.Naizvozvo, kuvandudzwa kwe microalgae extracellular vesicles kune yakakwira mukana mukushandurwa kwekiriniki uye maindasitiri.